α 1 -Antichymotrypsin Gene Polymorphism in Patients With Stroke

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a1-Antichymotrypsin Gene Polymorphism in Patients With Stroke

Background and Purpose—A role for proteolytic enzymes has been suggested in the pathogenesis of stroke. In a search for new genetic factors, we investigated the gene polymorphism of the serine protease inhibitor a1-antichymotrypsin (ACT) in patients with stroke. Methods—Two hundred twenty patients with acute ischemic stroke (n5182) and primary intracerebral hemorrhage (n538) and 70 control subj...

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1-Antichymotrypsin Polymorphism A Risk Factor for Hemorrhagic Stroke in Normotensive Subjects

Background and Purpose—Although genetic factors may be important in the pathogenesis of ischemic stroke (IS), little is known on the potential role of genes in most cases of hemorrhagic stroke (HS). Preliminary data showed that the TT genotype of the 1-antichymotrypsin (ACT) gene polymorphism was associated with HS, although it remained unsettled whether prevalence of this polymorphism might di...

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alpha(1)-antichymotrypsin polymorphism: a risk factor for hemorrhagic stroke in normotensive subjects.

BACKGROUND AND PURPOSE Although genetic factors may be important in the pathogenesis of ischemic stroke (IS), little is known on the potential role of genes in most cases of hemorrhagic stroke (HS). Preliminary data showed that the TT genotype of the alpha(1)-antichymotrypsin (ACT) gene polymorphism was associated with HS, although it remained unsettled whether prevalence of this polymorphism m...

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ژورنال

عنوان ژورنال: Stroke

سال: 2000

ISSN: 0039-2499,1524-4628

DOI: 10.1161/01.str.31.9.2103